2-Pyridincarbonitril - 2-Pyridincarbonitril

Structural formula
Structural formula of 2-pyridine carbonitrile
Name 2-Pyridincarbonitril
other names
  • 2-Cyanopyridin
  • Picolinonitril
  • Pyridin-2-carbonitril
Sum formula C 6 H 4 N 2
Brief description

light brown solid [1]

External identifiers / databases
CAS number 100-70-9
EC number 202-880-3
ECHA-InfoCard 100.002.619
PubChem 7522
ChemSpider 7241
Wikidata Q27103368
Molar mass 104.11 g · mol −1
Physical state



1,081 g·cm−3 (25 °C)[1]

Melting point

24–27 °C[1]

boiling point

212–215 °C[1]

Refractive index

1,529 (20 °C)[1]

safety instructions
GHS hazard labeling [1]
07 - Warning


H and P phrases H: 302​‐​319
P: 301+312+330​‐​305+351+338 [1]
Toxicological data

960 mg·kg−1 (LD50, Ratte, oral)[1]

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

2-pyridine carbonitrile is a chemical compound from the group of pyridines and nitriles .


2-pyridine carbonitrile is found in tobacco smoke . [4]

Extraction and presentation

2-pyridine carbonitrile can be obtained by the vapor phase ammoxidation of 2-methylpyridine with ammonia in the presence of air. [5]


2-pyridine carbonitrile is a light brown solid [1] that is soluble in water. [2]


2-pyridine carbonitrile is used as an important chemical intermediate for rimiterol hydrobromide and as a bronchodilator . It is also used as an intermediate for pharmaceuticals as well as for dyes and pigments and serves as a precursor of the respective amidate for protein modification by amidation . [2]

Individual evidence

  1. a b c d e f g h i j Data sheet 2-Pyridinecarbonitrile, 99% from Sigma-Aldrich , accessed on March 7, 2019 ( PDF ).
  2. a b c Data sheet 2-Cyanopyridine, 99% from AlfaAesar, accessed on March 7, 2019 ( PDF )(JavaScript required) .
  3. David R. Lide: CRC Handbook of Chemistry and Physics A Ready-reference Book of Chemical and Physical Data. CRC Press, 1995, ISBN 978-0-8493-0595-5, S. 490 ( limited preview in Google Book search).
  4. Alan Rodgman, Thomas A. Perfetti: The Chemical Components of Tobacco and Tobacco Smoke. CRC Press, 2016, ISBN 978-1-4665-1552-9, S. 751 ( limited preview in Google Book search).
  5. Entry on 2-pyridinecarbonitrile in the Hazardous Substances Data Bank , accessed on March 7, 2019.