4-tert-Butylphenol - 4-tert-Butylphenol
|other names|| |
|Brief description|| |
white solid with a phenolic odor 
|External identifiers / databases|
|Molar mass||150.22 g · mol −1|
|Physical state|| |
0,908 g·cm−3 (20 °C)
|boiling point|| |
very heavy in water (0.6 g l −1 at 20 ° C) 
|Authorization procedure under REACH|
Switzerland: 0.08 ml · m −3 or 0.5 mg · m −3 
|As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .|
Extraction and presentation
4- tert- butylphenol can be obtained by reacting phenol with tert- butanol in water at high pressure and temperatures around 250 ° C, whereby 2- tert- butylphenol is also formed.  It can also be obtained by reacting phenol with isobutylene , which also produces 3- tert- butylphenol . 
4- tert- butylphenol has depigmenting properties and can trigger allergies and leukoderma-like changes.  There is evidence that 4- tert- butylphenol acts as a hormonal disruptor in the environment . [8th]
4- tert- butylphenol was included in the EU's ongoing action plan ( CoRAP ) in 2014 in accordance with Regulation (EC) No. 1907/2006 (REACH) as part of substance evaluation . The effects of the substance on human health and the environment are re-evaluated and, if necessary, follow-up measures are initiated. The reasons for the uptake of 4- tert- butylphenol were concerns about high (aggregated) tonnage and as a potential endocrine disruptor . The reassessment took place from 2014 and was carried out by Germany . 
- OECD: Screening Information Dataset (SIDS) Initial Assessment Report (SIAR) für Phenol, 4-tert-butyl-, abgerufen am 19. April 2015.
- Entry on 4-tert-butylphenol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on November 9, 2019. Manufacturers or distributors can expand the harmonized classification and labeling .
- Entry in the SVHC list of the European Chemicals Agency , accessed on July 16, 2019.
- Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 98-54-4 or 4-tert-butylphenol ), accessed on November 2, 2015.
- U. Marcus Lindstrom: Organic Reactions in Water: Principles, Strategies and Applications. John Wiley & Sons, 2008, ISBN 0-470-99424-X, S. 280 ( limited preview in Google Book Search).
- George E. Totten: Handbook of Hydraulic Fluid Technology, Second Edition. CRC Press, 2011, ISBN 978-1-4200-8527-3, S. 840 ( limited preview in Google Book search).
- Umweltbundesamt: Substance assessments under REACH , accessed on April 20, 2015.
- J. Geier, H. Lessmann, among others: Impact of a job-related sensitization to p-tert-butylphenol-formaldehyde resin ( Memento of May 14, 2018 in the Internet Archive ). In: Dermatology in Work and Environment , Volume 58, No. 4/2010, pp. 190–192, accessed on April 20, 2015.
- Community rolling action plan ( CoRAP ) of the European Chemicals Agency (ECHA): 4-tert-butylphenol , accessed on March 26, 2019.