Biochemically, nucleotide analogs play two important roles: First, DNA and RNA polymerases represent one of the most important classes of enzymes that are the primary target of both anticancer and antiviral chemotherapeutic agents. More than a dozen clinically useful nucleotide analogs target viral RNA and DNA polymerases, and at least 8 clinically useful anticancer agents exert their antiproliferative effects through their interactions with DNA polymerases. [ 2 ] cell phones.
Almost all nucleotide analogs consist of a normal or slightly modified base conjugated to a modified sugar. Second, nucleotide analogs have provided a means of obtaining information about the functioning of DNA and RNA polymerases. [ 3 ]
Among the nucleotide analog drugs is adefovir dipivoxil , which is the prodrug of adefovir , an acyclic analog of deoxyadenosine-5-monophosphate (dAMP). This nucleotide has potent antiviral activity against the virus of hepatitis B and good bioavailability orally. The tenofovir disoproxil fumarate was the first inhibitor of reverse transcriptase nucleotide analogue marketed for the treatment of HIV infection. [ 4 ]
- Robert, D. Kuchta (2011). «Nucleotide Analogues as Probes for DNA and RNA Polymerases». Curr Protoc Chem Biol. 2 (2): 111-124. PMC 3149870. doi:10.1002/9780470559277.ch090203. Consultado el 26 de enero de 2018.
- Burton JR, Jr; Everson, GT (de agosto de 2009). «HCV NS5B polymerase inhibitors.». Clinics in liver disease 13 (3): 453-65. PMID 19628161.
- Berdis, AJ; McCutcheon, D (13 de agosto de 2007). «The use of non-natural nucleotides to probe template-independent DNA synthesis.». Chembiochem : a European journal of chemical biology 8 (12): 1399-408. PMID 17607682.
- Buti, María (May 2008). "Nucleoside and nucleotide analogs in the treatment of chronic hepatitis B virus". Infectious Diseases and Clinical Microbiology 26 : 32-38. doi : 10.1016 / S0213-005X (08) 76517-0 .